Scott Lemoine's picture
Where can the scientific studies be found that confirm aspartame was proven safe when tested on lab rats and monkeys? Also, can you please include a source to the unedited Bressler report to compare those safe studies with?

A:Expert Answer

Earlier this month, the European Food Safety Authority (EFSA) completed a full risk assessment on aspartame and concluded that aspartame and its breakdown products are safe for human consumption at current levels of exposure. To carry out this assessment, EFSA reviewed all available scientific research on aspartame, including both animal and human studies. More information about the assessment can be found here:


According to the EFSA’s press release, Dr. Alicja Mortensen, Chair of EFSA’s Panel on Food Additives and Nutrient Sources Added to Foods, said, “This opinion represents one of the most comprehensive risk assessments of aspartame ever undertaken. It’s a step forward in strengthening consumer confidence in the scientific underpinning of the EU food safety system and the regulation of food additives.”


For more information on aspartame, check out EFSA’s topic page and FAQ. Cathy Enright, Executive Director of the Council of Biotechnology Information, also explores aspartame in this response.  


We are unclear what you are asking with regard to the Bressler study and how it is related to GMOs. Please feel free to clarify and resubmit a new question.


Joseph Najjar's picture

This is what I found when I searched Bressler report:

From what I can tell, there is little to no accountability for some of the methods and materials. Individuals who were directly involved were no longer available to clarify their procedures, some under legal advising. What stood out the most to me, though, was this statement found near the bottom of the report:

" According to the submission to FDA, this study was intended to evaluate the safety and tumorigenic potential of SC-19192, diketopiperazine (5-benzyl-3, 6-dioxo-2-piperazine-acetic acid), which is a conversion product of aspartame, and to induce and define such adverse effects as might occur only at prodigious multiples of the estimated daily human intake. The commercial grade of aspartame (SC-18862) may contain up to 2
percent of the conversion product (DKP), according to Searle’s specifications."

They come right out and state that they are testing a conversion product of aspartame, not aspartame itself. Commercial grade aspartame contains less than 2% DKP, the conversion product. Also, they clearly state that they are testing amounts that far exceed an average human's daily consumption.

Above all else, The Bressler report was published in the 1970's, over 40 years ago. Regardless of that study, this is what more recent, relevant research shows

Scott Lemoine's picture

Could you do this... or I'm sure it's already been done hundreds of times. Take the results, whatever they are from the Bressler report and chart the differences in results compared to other test done to duplicate this one, and dismiss it.
For the most part the aspartame 'scare' seems to be fueled by the Bressler report and the infamous '4 out of 7 monkeys had 'grand mal' type seizures during testing' report. Where are the other test done to duplicate this one, and resolve this nonsense about aspartame causing ANY long term negative effect on rats and monkeys. I'm assuming the Waisman disaster that also fuels this 'conspiracy theory' has been duplicated and dismissed ad nauseam. This should be so simple to resolve, shouldn't it?
Where are all the "completely safe" test results?