Opponents of biotech enhanced crops have raised the theory that the act of alterning food crops through biotech techniques somehow introduces a novel safety risk not present with other non-regulated methods of altering the genetic endowment of food crops, whether that be conventional crossbreeding, mutigenisis (subjecting dna to mutating agents of radiation or chemicals such as how we get grapefruit), and a variety of other unregulated methods. In response to a question on this site, [http://gmoanswers.com/ask/how-can-you-presume-gmos-be-safe-when-it-was-only-recently-discovered-4-stranded-dna-exists-some] Martina Newell-McGloughlin stated that "Using modern analytical tools we can now demonstrate that all these forms of plant breeding introduce a variety of changes in DNA, ranging from point mutations and single base pair deletions and insertions, loss or acquisition of genes, to, . . . changes in numbers of whole chromosomes. By far and away the greatest changes at the molecular level are introduced by the various forms of mutation breeding."
Given what we are able to know through modern analytical tools about how any form of breeding causes disruptions in the DNA and gene expression and regulation, what theories or hypothesis have been advanced by the anti-GMO community as the mechanism by which the GE process introduces novel food safety risks that isn't present in other breeding methods, and what scientific evidence is available to support or discredit these theories? Alternatively, what concerns does the biotech community have with respect to the potential to introduce undesired collateral changes through genetic engineering in plant DNA and gene expression that may have implication for human health. How can you test for and minimize the chances for this occuring.