The Environmental Protection Agency’s (EPA’s) Pesticide Registration Process is designed to assess that pesticides used according to label directions do not pose any unreasonable adverse effects to either native or managed bees. Recent guidelines from EPA, Canada’s Pest Management Regulatory Agency (PMRA) and California’s Department of Pesticide Regulation (CDPR) define this process under which neonicotinoids continue to be assessed. In 2007, the National Academy of Science issued an extensive study, “Status of Pollinators in North America,” highlighting the central role that habitat has in maintaining native bee populations, and more recent publications support this. The crop protection industry has numerous activities ongoing to encourage the planting of more pollinator-friendly plants and research into plant species attractive to native pollinators. Extensive studies on honey bees (which are not native pollinators but are a useful indicator species) show that labeled uses of neonicotinoids do not impact bee-colony health. Although less research has been conducted on other pollinators, studies on bumblebees and leaf-cutting bees have shown that neonicotinoid applications can be safely used without harming these important pollinators.